A GLP-1R positive allosteric modulator
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GLP-1R Modulator L7-028

Item No. 41246

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N,6-triethyl-9,10-didehydro-1-(1-oxopropyl)-ergoline-8β-carboxamide
CAS Number
2648317-95-5
Synonyms
  • GLP-1 Receptor Modulator L7-028
  • Glucagon-like Peptide 1 Receptor Modulator L7-028
Molecular Formula
C24H28N2O3
Formula Weight
392.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1=CC(OC2CCCC2)=CC=C1)NC3=CC=CC(C(N4CCCCC4)=O)=C3
InChi Code
InChI=1S/C24H28N2O3/c27-23(18-8-7-13-22(17-18)29-21-11-2-3-12-21)25-20-10-6-9-19(16-20)24(28)26-14-4-1-5-15-26/h6-10,13,16-17,21H,1-5,11-12,14-15H2,(H,25,27)
InChi Key
QASJOTNVPCHDTC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    GLP-1R modulator L7-028 is a positive allosteric modulator of the glucagon-like peptide 1 receptor (GLP-1R).1 It enhances GLP-1 binding to GLP-1R (EC50 = 11.01 µM) and cAMP accumulation induced by GLP-1 (7-36) in CHO cells expressing GLP-1R.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, J., Yang, D., Cheng, X., et al. Allosteric modulators enhancing GLP-1 binding to GLP-1R via a transmembrane site. ACS Chem. Biol. 16(11), 2444-2452 (2021).