A Wnt/β-catenin signaling inhibitor
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Klotho-derived Peptide 6 (acetate)

Item No. 41263

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-glutaminyl-L-prolyl-L-valyl-L-valyl-L-threonyl-L-leucyl-L-tyrosyl-L-histidyl-L-tryptophyl-L-α-aspartyl-L-leucyl-L-prolyl-L-glutaminyl-L-arginyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-alanyl-L-tyrosylglycylglycyl-L-tryptophyl-L-alanyl-L-asparaginyl-L-arginyl-L-alanyl-L-leucyl-L-alanyl-L-α-aspartyl-L-histidine, acetate
Synonyms
  • Klotho (186-215) (human)
  • KP6
Molecular Formula
C159H232N46O44 • XC2H4O2
Formula Weight
3491.8
Purity
≥90%
Formulation (Request formulation change)
A solid
Peptide Sequence
QPVVTLYHWDLPQRLQDAYGGWANRALADH-OH
SMILES
O=C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@]([C@H](O[H])C)([H])C(N[C@H](C(N[C@@H](CC2=CC=C(O[H])C=C2)C(N[C@@H](CC3=CN([H])C=N3)C(N[C@@H](CC4=CN([H])C5=C4C=CC=C5)C(N[C@@H](CC(O)=O)C(N[C@H](C(N6CCC[C@H]6C(N[C@@H](CCC(N[H])=O)C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(N[C@@H](CCC(N[H])=O)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](CC7=CC=C(O[H])C=C7)C(NCC(NCC(N[C@@H](CC8=CN([H])C9=C8C=CC=C9)C(N[C@H](C(N[C@@H](CC(N[H])=O)C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CC%10=CN([H])C=N%10)C(O)=O)=O)=O)C)=O)CC(C)C)=O)C)=O)=O)=O)C)=O)=O)=O)=O)=O)C)=O)=O)=O)CC(C)C)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)[C@H](CCC(N[H])=O)N[H].CC(O)=O
InChi Code
InChI=1S/C159H232N46O44.C2H4O2/c1-74(2)52-102(139(230)180-83(16)133(224)191-112(64-125(217)218)149(240)200-115(157(248)249)61-90-69-170-73-178-90)188-130(221)80(13)179-135(226)98(30-22-48-171-158(165)166)185-147(238)110(62-121(164)212)190-132(223)82(15)181-140(231)107(58-87-66-173-96-28-20-18-26-93(87)96)183-123(214)71-175-122(213)70-176-134(225)105(56-85-34-38-91(207)39-35-85)189-131(222)81(14)182-141(232)111(63-124(215)216)196-138(229)100(43-46-119(162)210)186-142(233)103(53-75(3)4)192-136(227)99(31-23-49-172-159(167)168)184-137(228)101(44-47-120(163)211)187-150(241)116-32-25-51-205(116)156(247)114(55-77(7)8)199-148(239)113(65-126(219)220)197-145(236)108(59-88-67-174-97-29-21-19-27-94(88)97)194-146(237)109(60-89-68-169-72-177-89)195-144(235)106(57-86-36-40-92(208)41-37-86)193-143(234)104(54-76(5)6)198-154(245)129(84(17)206)203-153(244)128(79(11)12)202-152(243)127(78(9)10)201-151(242)117-33-24-50-204(117)155(246)95(160)42-45-118(161)209;1-2(3)4/h18-21,26-29,34-41,66-69,72-84,95,98-117,127-129,173-174,206-208H,22-25,30-33,42-65,70-71,160H2,1-17H3,(H2,161,209)(H2,162,210)(H2,163,211)(H2,164,212)(H,169,177)(H,170,178)(H,175,213)(H,176,225)(H,179,226)(H,180,230)(H,181,231)(H,182,232)(H,183,214)(H,184,228)(H,185,238)(H,186,233)(H,187,241)(H,188,221)(H,189,222)(H,190,223)(H,191,224)(H,192,227)(H,193,234)(H,194,237)(H,195,235)(H,196,229)(H,197,236)(H,198,245)(H,199,239)(H,200,240)(H,201,242)(H,202,243)(H,203,244)(H,215,216)(H,217,218)(H,219,220)(H,248,249)(H4,165,166,171)(H4,167,168,172);1H3,(H,3,4)/t80-,81-,82-,83-,84+,95-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,127-,128-,129-;/m0./s1
InChi Key
NRCFASGNOBTLBI-FDNSJZPQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $190

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    Product Description

    Klotho-derived peptide 6 (KP6) is a synthetic peptide fragment that corresponds to amino acids 186-215 of the anti-aging protein Klotho.1 It inhibits Wnt1-induced increases in fibronectin and α-smooth muscle actin (α-SMA) levels in HKC-8 human proximal tubular cells. KP6 (5 µg/ml) also inhibits Wnt3a-induced activation of β-catenin in a reporter assay using HEK293T cells. In vivo, KP6 (1 mg/kg) increases survival and decreases urine albumin levels, renal hypertrophy, and glomerular injury in a mouse model of diabetic kidney disease induced by streptozotocin (STZ; Item No. 13104), advanced oxidation protein products, and unilateral nephrectomy.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, X., Tan, H., Xu, J., et al. Klotho-derived peptide 6 ameliorates diabetic kidney disease by targeting Wnt/β-catenin signaling. Kidney Int. 102(3), 506-520 (2022).