A peptide derivative of GLP-2
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Product Type

Biochemicals
Peptides

Research Area

Immunology & Inflammation
Gastric Disease

Elsiglutide (acetate)

Item No. 41273

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Molecular Formula
C196H323N53O56 • XC2H4O2
Formula Weight
4318.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
[H]N[C@H](C(NCC(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CO)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@]([C@@H](C)O)([H])C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCCCN)C(N[C@]([C@H](CC)C)([H])C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)CC1=CNC2=C1C=CC=C2)=O)C)=O)=O)CC3=CC=CC=C3)=O)CC(O)=O)=O)=O)C)=O)C)=O)=O)C)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)CC5=CN=CN5.CC(O)=O
InChi Code
InChI=1S/C196H323N53O56.C2H4O2/c1-25-102(13)152(190(300)218-110(21)164(274)247-156(111(22)254)193(303)229-127(64-43-50-76-203)174(284)243-155(105(16)28-4)192(302)249-157(112(23)255)194(304)239-140(88-151(267)268)181(291)227-126(63-42-49-75-202)171(281)226-125(62-41-48-74-201)170(280)225-124(61-40-47-73-200)169(279)224-123(60-39-46-72-199)168(278)223-122(59-38-45-71-198)167(277)221-121(159(205)269)58-37-44-70-197)244-183(293)134(81-101(11)12)233-180(290)137(84-116-89-210-120-57-36-35-56-118(116)120)231-163(273)109(20)217-189(299)153(103(14)26-2)245-184(294)136(83-115-54-33-30-34-55-115)234-182(292)139(87-150(265)266)236-172(282)128(65-51-77-209-196(206)207)222-161(271)107(18)214-160(270)106(17)215-175(285)131(78-98(5)6)230-162(272)108(19)216-176(286)138(86-149(263)264)237-177(287)133(80-100(9)10)238-191(301)154(104(15)27-3)246-195(305)158(113(24)256)248-188(298)144(96-253)241-178(288)132(79-99(7)8)232-173(283)130(67-69-148(261)262)228-186(296)142(94-251)242-187(297)143(95-252)240-179(289)135(82-114-52-31-29-32-53-114)235-185(295)141(93-250)220-146(258)92-212-166(276)129(66-68-147(259)260)219-145(257)91-211-165(275)119(204)85-117-90-208-97-213-117;1-2(3)4/h29-36,52-57,89-90,97-113,119,121-144,152-158,210,250-256H,25-28,37-51,58-88,91-96,197-204H2,1-24H3,(H2,205,269)(H,208,213)(H,211,275)(H,212,276)(H,214,270)(H,215,285)(H,216,286)(H,217,299)(H,218,300)(H,219,257)(H,220,258)(H,221,277)(H,222,271)(H,223,278)(H,224,279)(H,225,280)(H,226,281)(H,227,291)(H,228,296)(H,229,303)(H,230,272)(H,231,273)(H,232,283)(H,233,290)(H,234,292)(H,235,295)(H,236,282)(H,237,287)(H,238,301)(H,239,304)(H,240,289)(H,241,288)(H,242,297)(H,243,284)(H,244,293)(H,245,294)(H,246,305)(H,247,274)(H,248,298)(H,249,302)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H,267,268)(H4,206,207,209);1H3,(H,3,4)/t102-,103-,104-,105-,106-,107-,108-,109-,110-,111+,112+,113+,119-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,152-,153-,154-,15
InChi Key
AZUQOMWSTYBKHM-ACXHLWDRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

    $198

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    10 mg

    $347

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    25 mg

    $495

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    Product Description

    Elsiglutide is a peptide derivative of glucagon-like peptide 2 (GLP-2).1 It increases jejunum and ileum crypt depth and villus height without disrupting gut microbiota diversity in rats when administered at a dose of 0.9 mg/kg four days per week. Elsiglutide decreases diarrhea severity and incidence induced by the dual inhibitor of EGFR and HER2 lapatinib (Item No. 11493) in rats. It prevents lapatinib-induced loss of body weight in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mayo, B.J., Secombe, K.R., Wignall, A.D., et al. The GLP-2 analogue elsiglutide reduces diarrhoea caused by the tyrosine kinase inhibitor lapatinib in rats. Cancer Chemother. Pharmacol. 85(4), 793-803 (2020).