A disulfide bond-containing ionizable cationic lipid
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4A3-SCC-10

Item No. 41276

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
((methylazanediyl)bis(propane-3,1-diyl))bis(8,14-dioxo-7,15-dioxa-3,4,18,19-tetrathia-11-azahenicosane-11,1,21-triyl) tetrakis(3-(decylthio)-2-methylpropanoate)
CAS Number
3082361-42-7
Molecular Formula
C91H171N3O16S12
Formula Weight
1948.1
Purity
≥90%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Ethanol: Sparingly soluble: 1-10 mg/ml
SMILES
CN(CCCN(CCC(OCCSSCCOC(C(C)CSCCCCCCCCCC)=O)=O)CCC(OCCSSCCOC(C(CSCCCCCCCCCC)C)=O)=O)CCCN(CCC(OCCSSCCOC(C(CSCCCCCCCCCC)C)=O)=O)CCC(OCCSSCCOC(C(CSCCCCCCCCCC)C)=O)=O
InChi Code
InChI=1S/C91H171N3O16S12/c1-10-14-18-22-26-30-34-38-64-111-76-80(5)88(99)107-60-72-119-115-68-56-103-84(95)44-52-93(53-45-85(96)104-57-69-116-120-73-61-108-89(100)81(6)77-112-65-39-35-31-27-23-19-15-11-2)50-42-48-92(9)49-43-51-94(54-46-86(97)105-58-70-117-121-74-62-109-90(101)82(7)78-113-66-40-36-32-28-24-20-16-12-3)55-47-87(98)106-59-71-118-122-75-63-110-91(102)83(8)79-114-67-41-37-33-29-25-21-17-13-4/h80-83H,10-79H2,1-9H3
InChi Key
KTIRKMBPBLQRPY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    4A3-SCC-10 is a disulfide bond-containing biodegradable ionizable cationic lipid (pKa = 6.22) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing 4A3-SCC-10 and encapsulating a Cy5-RNA reporter have improved endosomal escape ability over Cy5-RNA-encapsulated LNPs containing 4A3-SC-10, which does not contain disulfide bonds, in HeLa cells. LNPs containing 4A3-SCC-10 and encapsulating an mRNA luciferase reporter selectively accumulate in mouse liver after intravenous administration.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, Z., Tian, Y., Yang, J., et al. Modular design of biodegradable ionizable lipids for improved mRNA delivery and precise cancer metastasis delineation in vivo. J. Am. Chem. Soc. 145(44), 24302-24314 (2023).