An IKZF2 degrader
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NVP-DKY709

Item No. 41295

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[1,3-dihydro-1-oxo-5-[1-(phenylmethyl)-4-piperidinyl]-2H-isoindol-2-yl]-2,6-piperidinedione
CAS Number
2291360-73-9
Molecular Formula
C25H27N3O3
Formula Weight
417.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C1C2=CC=C(C3CCN(CC3)CC4=CC=CC=C4)C=C2CN1C5C(NC(CC5)=O)=O
InChi Code
InChI=1S/C25H27N3O3/c29-23-9-8-22(24(30)26-23)28-16-20-14-19(6-7-21(20)25(28)31)18-10-12-27(13-11-18)15-17-4-2-1-3-5-17/h1-7,14,18,22H,8-13,15-16H2,(H,26,29,30)
InChi Key
OMISHRJQMYQPMG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $244

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    10 mg

    $405

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    25 mg

    $675

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    Cayman Chemical
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    Product Description

    NVP-DKY709 is a degrader of Ikaros family zinc finger protein 2 (IKZF2) with a half-maximal degradation concentration (DC50) value of 4 nM.1 It is selective for IKZF2 over 8,656 other proteins, including IKZF1, IKZF3, and IKZF5, at 2.5 µM, but it does degrade IKZF4, which has the same zinc finger 2 β-hairpin sequence as IKZF2, and Sal-like protein 4 (SALL4; DC50s = 13 and 2 nM, respectively). It increases IL-2 secretion induced by phytohemagglutinin in Jurkat T cells in a concentration-dependent manner. NVP-DKY709 (100 mg/kg), alone or in combination with an antibody against programmed death protein 1 (PD-1), decreases tumor volume in an MDA-MB-231 humanized mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bonazzi, S., d'Hennezel, E., Beckwith, R.E., et al. Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy. Cell Chem. Biol. 30(3), 235-247.e212 (2023).