A TRPA1 inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

BAY-390

Item No. 41313

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2R-[(4-fluorophenyl)amino]-1R-(trifluoromethyl)-cyclohexanol
CAS Number
2741956-55-6
Molecular Formula
C13H15F4NO
Formula Weight
277.3
Purity
≥95%
Formulation (Request formulation change)
A solution in ethanol
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlEthanol: Slightly Soluble: 0.1-1 mg/ml
SMILES
FC(F)(F)[C@@](O)(CCCC1)[C@@H]1NC2=CC=C(C=C2)F
InChi Code
InChI=1S/C13H15F4NO/c14-9-4-6-10(7-5-9)18-11-3-1-2-8-12(11,19)13(15,16)17/h4-7,11,18-19H,1-3,8H2/t11-,12-/m1/s1
InChi Key
IESAJAZKMLPVIB-VXGBXAGGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $28

    Add

    5 mg

    $117

    Add

    10 mg

    $207

    Add

    25 mg

    $447

    Add
    Product Description

    BAY-390 is an inhibitor of transient receptor potential ankyrin 1 (TRPA1; IC50s = 16 and 63 nM for the human and rat receptor, respectively).1 It is selective for TRPA1 over a variety of receptors, ion channels, transporters, and enzymes at 10 µM but weakly inhibits estrogen receptor α (ERα), progesterone receptor B (PR-B), and the dopamine transporter (DAT; IC50s = 5,000, 5,000, and 1,200 nM, respectively). BAY-390 (3-10 mg/kg) reduces the number of flinches and the duration of paw licking in a rat model of nocifensive behavior induced by the TRPA1 agonist cinnamaldehyde and reduces inflammatory pain induced by complete Freund’s adjuvant (CFA) in rats. It also reverses mechanical allodynia in a rat model of neuropathic pain induced by spinal nerve ligation when administered at a dose of 90 mg/kg twice per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mesch, S., Walter, D., Laux-Biehlmann, A., et al. Discovery of BAY-390, a selective CNS penetrant chemical probe as transient receptor potential ankyrin 1 (TRPA1) antagonist. J. Med. Chem. 66(2), 1583-1600 (2023).