A F508del-CFTR corrector
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A-1596586

Item No. 41316

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[(2R,4R)-2-(3,4-dimethoxyphenyl)-3,4-dihydro-7-methoxy-2H-1-benzopyran-4-yl]-cyclopropanecarboxamide
CAS Number
1918142-34-3
Molecular Formula
C29H27F2NO7
Formula Weight
539.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1(CC1)C2=CC(OC(F)(F)O3)=C3C=C2)N[C@H](C[C@H](C(C=C4)=CC(OC)=C4OC)OC5=C6)C5=CC=C6OC
InChi Code
InChI=1S/C29H27F2NO7/c1-34-18-6-7-19-20(15-23(37-24(19)14-18)16-4-8-21(35-2)25(12-16)36-3)32-27(33)28(10-11-28)17-5-9-22-26(13-17)39-29(30,31)38-22/h4-9,12-14,20,23H,10-11,15H2,1-3H3,(H,32,33)/t20-,23-/m1/s1
InChi Key
KDOQEEMQPHIANX-NFBKMPQASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $229

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    10 mg

    $351

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    25 mg

    $742

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    Product Description

    A-1596586 is a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) bearing the F508 deletion (F508del) mutation.1 It increases CFTR levels in CFBE41o- bronchial epithelial cells expressing F508del-CFTR fused to HRP (EC50 = 0.13 µM) and the transepithelial current in primary human bronchial epithelial cells isolated from a patient with cystic fibrosis with the F508del-CFTR mutation (EC50 = 0.028 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rooney, T.P.C., Aldred, G.G., Boffey, H.K., et al. The identification of potent, selective, and brain penetrant PI5P4Kγ inhibitors as in vivo-ready tool molecules. J. Med. Chem. 66(1), 804-821 (2023).