A dopamine D4 receptor agonist
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UCSF924

Item No. 41317

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-methyl-2-[[(3-phenoxypropyl)amino]methyl]-4-quinolinol
CAS Number
1434515-70-4
Molecular Formula
C20H22N2O2
Formula Weight
322.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlDMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
OC1=CC(CNCCCOC2=CC=CC=C2)=NC3=C1C=C(C)C=C3
InChi Code
InChI=1S/C20H22N2O2/c1-15-8-9-19-18(12-15)20(23)13-16(22-19)14-21-10-5-11-24-17-6-3-2-4-7-17/h2-4,6-9,12-13,21H,5,10-11,14H2,1H3,(H,22,23)
InChi Key
RPHDOVLXDYWDGF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $141

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    10 mg

    $264

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    25 mg

    $572

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    Product Description

    UCSF924 is a dopamine D4 receptor agonist.1 It selectively induces β-arrestin translocation over Gαi/o signaling in HEK293T cells expressing human dopamine D4 receptors by 7.4-fold at 1 µM. UCSF924 selectively induces cAMP accumulation in HEK293T cells expressing human dopamine D4 receptors (EC50 = 4.2 nM) over HEK293T cells expressing human dopamine D2 or dopamine D3 receptors (EC50s = >10 µM for both) and induces β-arrestin recruitment in HTLA cells expressing human dopamine D4 receptors over a panel of HTLA cells expressing one of 320 non-olfactory G protein-coupled receptors (GPCRs) at 1 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, S., Wacker, D., Levit, A., et al. D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science 358(6361), 381-386 (2017).