A γ-secretase inhibitor
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GSM2

Item No. 41322

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-fluoro-1,3,4,5-tetrahydro-3-[4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-2H-1-benzazepin-2-one
CAS Number
1093978-89-2
Synonyms
  • γ-Secretase Modulator 2
  • γ-SM2
Molecular Formula
C25H22F4N6O2
Formula Weight
514.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C1N(C2=CC=CC(F)=C2CCC1N3C=C(C4=CC(OC)=C(N5C=NC(C)=C5)C=C4)N=N3)CC(F)(F)F
InChi Code
InChI=1S/C25H22F4N6O2/c1-15-11-33(14-30-15)21-8-6-16(10-23(21)37-2)19-12-35(32-31-19)22-9-7-17-18(26)4-3-5-20(17)34(24(22)36)13-25(27,28)29/h3-6,8,10-12,14,22H,7,9,13H2,1-2H3
InChi Key
AAHNBILIYONQLX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $109

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    5 mg

    $382

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    Product Description

    GSM2 is an inhibitor of γ-secretase.1 It inhibits the production of amyloid-β (1-42) (Aβ42) in SH-SY5Y neuroblastoma cells overexpressing SPA4CT, which is a peptide containing the N-terminal signal peptide and C-terminal residues of amyloid precursor protein (APP).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fischer, C., Munoz, B., Zultanski, S., et al. Triazole derivatives for treating Alzheimer’s disease and related conditions. (2008).