A GLP-1R agonist
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ECC5004

Item No. 41324

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[1-[2-[[(4S)-2-(3-cyclopropyl-4-fluorophenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazol-1-yl]-2,4,6,7-tetrahydro-4-methyl-5H-pyrazolo[4,3-c]pyridin-5-yl]carbonyl]-7-[(4R)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-3-indolizinyl]cyclopropyl]-1,2,4-oxadiazol-5(2H)-one
CAS Number
3011682-51-9
Synonyms
  • AZD 5004
Molecular Formula
C48H46F2N10O5
Formula Weight
880.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(N1[C@H](C2=C(N3C=CN(C4=CC=C(N(C)N=C5)C5=C4F)C3=O)N(C6=CC(C7CC7)=C(C=C6)F)N=C2CC1)C)C8=C(N9C(C=C([C@H]%10CC(C)(OCC%10)C)C=C9)=C8)C%11(C%12=NOC(N%12)=O)CC%11
InChi Code
InChI=1S/C48H46F2N10O5/c1-26-39-36(53-60(30-7-8-35(49)32(22-30)27-5-6-27)42(39)59-19-18-58(46(59)63)38-10-9-37-34(40(38)50)25-51-55(37)4)12-17-56(26)43(61)33-23-31-21-28(29-13-20-64-47(2,3)24-29)11-16-57(31)41(33)48(14-15-48)44-52-45(62)65-54-44/h7-11,16,18-19,21-23,25-27,29H,5-6,12-15,17,20,24H2,1-4H3,(H,52,54,62)/t26-,29+/m0/s1
InChi Key
JMKBTILBGROESC-LITSAYRRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $215

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    Product Description

    ECC5004 is an agonist of glucagon-like peptide 1 receptor (GLP-1R).1 It induces cAMP accumulation in HEK293 cells expressing human GLP-1R with an EC50 value less than 20 nM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ren, Z., Sun, X., Zhou, J., et al. Substituted imidazoles as GLP-I receptor agonists. (2023).