An FTase inhibitor
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ABT-100

Item No. 41355

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[(2S)-2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethoxy]-4′-(trifluoromethoxy)-[1,1′-biphenyl]-3-carbonitrile
CAS Number
450839-40-4
Synonyms
  • A-367074
Molecular Formula
C27H19F3N4O3
Formula Weight
504.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
FC(F)(OC1=CC=C(C2=C(OC[C@](C3=CC=C(C#N)C=C3)(C4=CN=CN4C)O)C=CC(C#N)=C2)C=C1)F
InChi Code
InChI=1S/C27H19F3N4O3/c1-34-17-33-15-25(34)26(35,21-7-2-18(13-31)3-8-21)16-36-24-11-4-19(14-32)12-23(24)20-5-9-22(10-6-20)37-27(28,29)30/h2-12,15,17,35H,16H2,1H3/t26-/m0/s1
InChi Key
HEUVRFNVTLGKMZ-SANMLTNESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    ABT-100 is an inhibitor of farnesyltransferase (FTase).1 It inhibits Ras farnesylation but not Rap1A geranylgeranylation in HepG2 and Huh7 cells when used at a concentration of 20 µM. ABT-100 (2-20 µM) inhibits the proliferation of the same cells. In vivo, ABT-100 (39 mg/kg per day) increases body weight and percent survival, improves grip strength, and decreases the number of rib fractures in a Zmpste24-/- mouse model of progeria.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Carloni, V., Vizzutti, F., and Pantaleo, P. Farnesyltransferase inhibitor, ABT-100, is a potent liver cancer chemopreventive agent. Clin. Cancer Res. 11(11), 4266-4274 (2005).

    2. Fong, L.G., Frost, D., Meta, M., et al. A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. Science 311, 1621-1623 (2006).