A positive allosteric modulator of M1 mAChRs
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

MSD-M1PAM

Item No. 41358

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[4-cyano-4-(2-pyridinyl)-1-piperidinyl]methyl]-4-oxo-4H-quinolizine-3-carboxylic acid
CAS Number
1144504-35-7
Synonyms
  • PQCA
Molecular Formula
C22H20N4O3
Formula Weight
388.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(O)C1=CC(CN2CCC(C3=NC=CC=C3)(C#N)CC2)=C4C=CC=CN4C1=O
InChi Code
InChI=1S/C22H20N4O3/c23-15-22(19-6-1-3-9-24-19)7-11-25(12-8-22)14-16-13-17(21(28)29)20(27)26-10-4-2-5-18(16)26/h1-6,9-10,13H,7-8,11-12,14H2,(H,28,29)
InChi Key
RJTJRVASUFIDQM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $57

    Add

    1 mg

    $102

    Add
    Product Description

    MSD-M1PAM is a positive allosteric modulator of M1 muscarinic acetylcholine receptors (mAChRs).1 It enhances ACh-induced calcium production in a calcium mobilization assay when used at concentrations ranging from 0.1 to 10 µM. In vivo, MSD-M1PAM (1-30 mg/kg) reverses scopolamine-induced deficits in freezing behavior in mice. It also attenuates deficits in self-ordered spatial search in cynomolgus macaques and in the object retrieval detour task in rhesus macaques.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kuduk, S.D., Chang, R.K., Di Marco, C.N., et al. Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold. J. Med. Chem. 54(13), 4773-4780 (2011).

    2. Uslaner, J.M., Eddins, D., Puri, V., et al. The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque. Psychopharmacology (Berl) 225(1), 21-30 (2013).