A positive allosteric modulator of M1 mAChRs
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MSD-M1PAM

Item No. 41358

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[4-cyano-4-(2-pyridinyl)-1-piperidinyl]methyl]-4-oxo-4H-quinolizine-3-carboxylic acid
CAS Number
1144504-35-7
Synonyms
  • PQCA
Molecular Formula
C22H20N4O3
Formula Weight
388.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(O)C1=CC(CN2CCC(C3=NC=CC=C3)(C#N)CC2)=C4C=CC=CN4C1=O
InChi Code
InChI=1S/C22H20N4O3/c23-15-22(19-6-1-3-9-24-19)7-11-25(12-8-22)14-16-13-17(21(28)29)20(27)26-10-4-2-5-18(16)26/h1-6,9-10,13H,7-8,11-12,14H2,(H,28,29)
InChi Key
RJTJRVASUFIDQM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    Product Description

    MSD-M1PAM is a positive allosteric modulator of M1 muscarinic acetylcholine receptors (mAChRs).1 It enhances ACh-induced calcium production in a calcium mobilization assay when used at concentrations ranging from 0.1 to 10 µM. In vivo, MSD-M1PAM (1-30 mg/kg) reverses scopolamine-induced deficits in freezing behavior in mice. It also attenuates deficits in self-ordered spatial search in cynomolgus macaques and in the object retrieval detour task in rhesus macaques.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kuduk, S.D., Chang, R.K., Di Marco, C.N., et al. Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold. J. Med. Chem. 54(13), 4773-4780 (2011).

    2. Uslaner, J.M., Eddins, D., Puri, V., et al. The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque. Psychopharmacology (Berl) 225(1), 21-30 (2013).