A synthetic intermediate in the synthesis of capzimin
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Capzimin Dimer

Item No. 41364

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8,8′-dithiobis[N-[2-(2-thiazolyl)ethyl]-3-quinolinecarboxamide
CAS Number
2084868-04-0
Molecular Formula
C30H24N6O2S4
Formula Weight
628.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C(C1=CN=C2C(SSC3=CC=CC4=CC(C(NCCC5=NC=CS5)=O)=CN=C34)=CC=CC2=C1)NCCC6=NC=CS6
InChi Code
InChI=1S/C30H24N6O2S4/c37-29(33-9-7-25-31-11-13-39-25)21-15-19-3-1-5-23(27(19)35-17-21)41-42-24-6-2-4-20-16-22(18-36-28(20)24)30(38)34-10-8-26-32-12-14-40-26/h1-6,11-18H,7-10H2,(H,33,37)(H,34,38)
InChi Key
RNEOHKZPZKEZCQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $101

    Add

    10 mg

    $191

    Add

    25 mg

    $451

    Add

    50 mg

    $801

    Add
    Product Description

    Capzimin dimer is a synthetic intermediate in the synthesis of capzimin, an inhibitor of the proteosome 19S subunit Rpn11.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Perez, C., Li, J., Parlati, F., et al. Discovery of an inhibitor of the proteasome subunit Rpn11. J. Med. Chem. 60(4), 1343-1361 (2017).

    2. Li, J., Yakushi, T., Parlati, F., et al. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat. Chem. Biol. 13(5), 486-493 (2017).