A METAP2 inhibitor
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TP-004

Item No. 41368

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[4-methyl-5-[6-(trifluoromethyl)-1H-indazol-4-yl]-2-pyrimidinyl]-3R-pyrrolidinol
CAS Number
1454299-21-8
Molecular Formula
C17H16F3N5O
Formula Weight
363.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlMethanol: Sparingly soluble: 1-10 mg/ml
SMILES
FC(F)(C1=CC(C2=CN=C(N=C2C)N3CC[C@@H](O)C3)=C4C=NNC4=C1)F
InChi Code
InChI=1S/C17H16F3N5O/c1-9-13(6-21-16(23-9)25-3-2-11(26)8-25)12-4-10(17(18,19)20)5-15-14(12)7-22-24-15/h4-7,11,26H,2-3,8H2,1H3,(H,22,24)/t11-/m1/s1
InChi Key
BNTAEJNPQLMGDJ-LLVKDONJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $109

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    5 mg

    $409

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    Product Description

    TP-004 is an inhibitor of methionyl aminopeptidase 2 (METAP2; IC50 = 6 nM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheruvallath, Z., Tang, M., McBride, C., et al. Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 1. Bioorg. Med. Chem. Lett. 26(12), 2774-2778 (2016).