An ionizable cationic lipid
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O12-D3-I3

Item No. 41385

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
didodecyl 3,3'-((3-(2-amino-3-(1H-imidazol-4-yl)propanamido)propyl)azanediyl)dipropionate
CAS Number
3041009-08-6
Molecular Formula
C39H73N5O5
Formula Weight
692.0
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
O=C(NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O)C(N)CC1=CNC=N1
InChi Code
InChI=1S/C39H73N5O5/c1-3-5-7-9-11-13-15-17-19-21-30-48-37(45)24-28-44(27-23-26-42-39(47)36(40)32-35-33-41-34-43-35)29-25-38(46)49-31-22-20-18-16-14-12-10-8-6-4-2/h33-34,36H,3-32,40H2,1-2H3,(H,41,43)(H,42,47)
InChi Key
WRGZOVIIXQZLPE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    O12-D3-I3 is an ionizable cationic lipid (pKa = 6.39) that has been used in the generation of lipid nanoparticles (LNPs) for siRNA delivery in vitro and in vivo.1 LNPs containing O12-D3-I3 and encapsulating ferrocene and siRNA targeting nuclear factor erythroid 2-related factor 2 (Nrf2) or the system xc- cystine/glutamate transporter decrease viability of HepG2 hepatocellular carcinoma cells. LNPs containing O12-D3-I3 and an mRNA reporter selectively accumulate in the tumor and liver over the lungs, kidneys, spleen, and heart in an MCF-7 breast cancer mouse xenograft model. LNPs containing O12-D3-I3 and encapsulating ferrocene and either Nrf2-targeting siRNA or system xc- cystine/glutamate transporter-targeting siRNA reduce tumor growth and volume in an MCF-7 mouse xenograft model. LNPs containing O12-D3-I3 and encapsulating siRNA targeting Factor VII decrease hepatocyte Factor VII mRNA levels in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, Y., He, F., Chen, L., et al. Imidazolyl lipids enhanced LNP endosomal escape for ferroptosis RNAi treatment of cancer. Small 20(40), e2402362 (2024).