An ionizable cationic lipid
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119-23

Item No. 41386

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9Z-octadecenoic acid, 6-[[3-(dimethylamino)propyl][(9Z)-1-oxo-9-octadecen-1-yl]amino]-7-oxo-7-(tricyclo[3.3.1.13,7]dec-1-ylamino)heptyl ester
CAS Number
2953044-98-7
Molecular Formula
C58H105N3O4
Formula Weight
908.5
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
CCCCCCCC/C=C\CCCCCCCC(N(C(CCCCCOC(CCCCCCC/C=C\CCCCCCCC)=O)C(NC1(C[C@@H](C2)C3)CC3CC2C1)=O)CCCN(C)C)=O
InChi Code
InChI=1S/C58H105N3O4/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-35-40-55(62)61(43-38-42-60(3)4)54(57(64)59-58-48-51-45-52(49-58)47-53(46-51)50-58)39-34-33-37-44-65-56(63)41-36-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h19-22,51-54H,5-18,23-50H2,1-4H3,(H,59,64)/b21-19-,22-20-/t51-,52?,53?,54?,58?
InChi Key
IGAVEEMYGLJEMW-MVCNXQAVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    119-23 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 LNPs containing 119-23 and encapsulating an mRNA reporter show greater intramuscular transfection efficacy compared to LNPs containing the ionizable cationic lipids SM-102 (Item No. 33474) or DLin-MC3-DMA (Item No. 34364) in mice. 119-23-containing LNPs accumulate in mouse hepatic and splenic immune cells to a greater extent than SM-102-containing LNPs. LNPs containing 119-23 and encapsulating mRNA encoding human erythropoietin (hEPO) increase serum hEPO levels in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, B., Raji, I.O., Gordon, A.G.R., et al. Accelerating ionizable lipid discovery for mRNA delivery using machine learning and combinatorial chemistry. Nat. Mater. 23(7), 1002-1008 (2024).