A peptide inhibitor of cell adhesion
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FNIII14 (sodium salt)

Item No. 41396

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-threonyl-L-α-glutamyl-L-alanyl-L-threonyl-L-isoleucyl-L-threonylglycyl-L-leucyl-L-α-glutamyl-L-prolylglycyl-L-threonyl-L-α-glutamyl-L-tyrosyl-L-threonyl-L-isoleucyl-L-tyrosyl-L-valyl-L-isoleucyl-L-alanyl-L-leucine, sodium salt
Synonyms
  • FNIII14-2
Molecular Formula
C103H163N21O35 • XNa
Formula Weight
2255.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
TEATITGLEPGTWYTIYVIAL-OH
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mL
SMILES
[H]N[C@]([C@@H](C)O)([H])C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@]([C@H](CC)C)([H])C(N[C@]([C@@H](C)O)([H])C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N1CCC[C@H]1C(NCC(N[C@]([C@@H](C)O)([H])C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](C(C)C)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)C)=O)=O)=O)CC2=CC=C(O)C=C2)=O)=O)=O)CC3=CC=C(O)C=C3)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O.[Na]
InChi Code
InChI=1S/C103H163N21O35.Na/c1-20-49(10)78(96(151)108-52(13)85(140)115-69(103(158)159)41-47(6)7)118-95(150)77(48(8)9)117-90(145)68(43-60-27-31-62(131)32-28-60)114-97(152)79(50(11)21-2)119-101(156)84(58(19)129)122-91(146)67(42-59-25-29-61(130)30-26-59)113-88(143)64(34-37-74(136)137)111-99(154)82(56(17)127)116-72(133)45-105-92(147)70-24-23-39-124(70)102(157)65(35-38-75(138)139)112-89(144)66(40-46(4)5)109-71(132)44-106-94(149)81(55(16)126)123-98(153)80(51(12)22-3)120-100(155)83(57(18)128)121-86(141)53(14)107-87(142)63(33-36-73(134)135)110-93(148)76(104)54(15)125;/h25-32,46-58,63-70,76-84,125-131H,20-24,33-45,104H2,1-19H3,(H,105,147)(H,106,149)(H,107,142)(H,108,151)(H,109,132)(H,110,148)(H,111,154)(H,112,144)(H,113,143)(H,114,152)(H,115,140)(H,116,133)(H,117,145)(H,118,150)(H,119,156)(H,120,155)(H,121,141)(H,122,146)(H,123,153)(H,134,135)(H,136,137)(H,138,139)(H,158,159);/t49-,50-,51-,52-,53-,54+,55+,56+,57+,58+,63-,64-,65-,66-,67-,68-,69-,70-,76-,77-,78-,79-,80-,81-,82-,83-,84-;/m0./s1
InChi Key
WZQPLUSPERBDPM-VHCTWGPZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    FNIII14 is an inhibitor of cell adhesion and a peptide derived from the 14th type III repeat, which is part of heparin-binding domain 2, of human, mouse, and rat fibronectin.1,2 It inhibits the adhesion of A375-SM melanoma cells to fibronectin-coated plates when used at a concentration of 200 µg/ml.1 FNIII14 (100 µg/ml) inhibits the binding of an antibody targeting the active conformation of the fibronectin receptor β1 integrin on K562 cells, which endogenously express integrin α5β1 as its only β1 integrin, and induces the differentiation of ST 13 fibroblasts into adipocytes.2 It decreases atherosclerotic plaque formation in Ldlr-/- mice fed a Western diet.3 FNIII14, in combination with the antitumor antibiotic doxorubicin (Item No. 15007), reduces metastatic tumor burden in a 4T1 murine mammary model of metastasis.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fukai, F., Hasabe, S., Ueki, M., et al. Identification of the anti-adhesive site buried within the heparin-binding domain of fibronectin. J. Biochem. 121(2), 189-192 (1997).

    2. Kamiya, S., Kato, R., Wakabayashi, M., et al. Fibronectin peptides derived from two distinct regions stimulate adipocyte differentiation by preventing fibronectin matrix assembly. Biochemistry 41(9), 3270-3277 (2002).

    3. Iyoda, T., Ohishi, A., Wang, Y., et al. Bioactive TNIIIA2 sequence in tenascin-C is responsible for macrophage foam cell transformation; Potential of FNIII14 peptide derived from fibronectin in suppression of atherosclerotic plaque formation. Int. J. Mol. Sci. 25(3), 1825 (2024).

    4. Iyoda, T., Nagamine, Y., Nakane, Y., et al. Coadministration of the FNIII14 peptide synergistically augments the anti-cancer activity of chemotherapeutic drugs by activating pro-apoptotic bim. PLoS One 11(9), e0162525 (2016).