An aminoglycoside antibiotic
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Alternative(s)
14596Tobramycin
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Tobramycin (sulfate)

Item No. 41453

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-D-streptamine, sulfuric acid
CAS Number
49842-07-1
Synonyms
  • Deoxykanamycin B
  • Distobram
  • Gernebcin
Molecular Formula
C18H37N5O9 • 5/2H2SO4
Formula Weight
712.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
N[C@@H]1[C@@H](O[C@]2([H])[C@H](N)C[C@H](O)[C@@H](CN)O2)[C@H](O)[C@@H](O[C@@]3([H])O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C1.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O
InChi Code
InChI=1S/C18H37N5O9.3H2O4S/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18;3*1-5(2,3)4/h5-18,24-28H,1-4,19-23H2;3*(H2,1,2,3,4)/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+;;;/m0.../s1
InChi Key
GQWARZLINPDNEQ-QNEWSYAISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Tobramycin is an aminoglycoside antibiotic.1 It binds to the 30S ribosomal subunit, inhibiting protein synthesis. Tobramycin is active against a variety of Gram-positive and Gram-negative bacteria, including several strains of S. aureus, P. aeruginosa, E. coli, K. pneumoniae, and Enterobacter (mean MICs = 0.2, 0.6, 1.2, 0.8, and 0.8 µg/ml, respectively). It reduces the number of colony-forming units (CFUs) in several mouse models of thigh infection.2 Formulations containing tobramycin have been used in the treatment of Gram-positive and Gram-negative bacterial infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Neu, H.C. Tobramycin: An overview. J. Infect. Dis. 134(Suppl. 1), S3-S19 (1976).

    2. Fantin, B., Leggett, J., Ebert, S., et al. Correlation between in vitro and in vivo activity of antimicrobial agents against gram-negative bacilli in a murine infection model. Antimicrob. Agents Chemother. 35(7), 1413-1422 (1991).