An α-defensin peptide
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Defensin NP-3A (60-93) (rabbit) (trifluoroacetate salt)

Item No. 41458

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-isoleucyl-L-cysteinyl-L-alanyl-L-cysteinyl-L-arginyl-L-arginyl-L-arginyl-L-phenylalanyl-L-cysteinyl-L-prolyl-L-asparaginyl-L-seryl-L-a-glutamyl-L-arginyl-L-phenylalanyl-L-serylglycyl-L-tyrosyl-L-cysteinyl-L-arginyl-L-valyl-L-asparaginylglycyl-L-alanyl-L-arginyl-L-tyrosyl-L-valyl-L-arginyl-L-cysteinyl-L-cysteinyl-L-seryl-L-arginyl-L-arginine, trifluoroacetate salt
Synonyms
  • Corticostatin 1
  • NP-3A
Molecular Formula
C163H265N63O44S6 • XCF3COOH
Formula Weight
4003.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
GICACRRRFCPNSERFSGYCRVNGARYVRCCSRR-OH
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mLWater: Slightly Soluble: 0.1-1 mg/mL
SMILES
O=C(N[C@@](C(N[C@@H](CS[H])C(N[C@H](C(N[C@@H](CS[H])C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(N[C@@H](CS[H])C(N1CCC[C@H]1C(N[C@@H](CC(N[H])=O)C(N[C@@H](CO[H])C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@H](C(N[C@@H](CO[H])C(NCC(N[C@@H](CC2=CC=C(O[H])C=C2)C(N[C@@H](CS[H])C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](C(C)C)C(N[C@@H](CC(N[H])=O)C(NCC(N[C@H](C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CC3=CC=C(O[H])C=C3)C(N[C@@H](C(C)C)C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CS[H])C(N[C@@H](CS[H])C(N[C@@H](CO[H])C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CCC/N=C(N[H])/N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)C)=O)=O)([H])[C@@H](C)CC)CN[H].OC(C(F)(F)F)=O
InChi Code
InChI=1S/C163H265N63O44S6.C2HF3O2/c1-9-80(6)123(223-117(234)66-164)152(267)221-108(72-271)144(259)197-82(8)125(240)217-109(73-272)145(260)204-91(32-18-52-187-157(171)172)129(244)200-90(31-17-51-186-156(169)170)128(243)201-93(34-20-54-189-159(175)176)132(247)210-101(61-84-28-14-11-15-29-84)139(254)222-113(77-276)153(268)226-59-25-39-114(226)149(264)212-104(65-116(166)233)140(255)215-106(70-228)143(258)206-97(48-49-120(237)238)135(250)202-94(35-21-55-190-160(177)178)133(248)209-100(60-83-26-12-10-13-27-83)138(253)214-105(69-227)127(242)195-68-119(236)198-99(62-85-40-44-87(230)45-41-85)137(252)219-110(74-273)146(261)205-96(37-23-57-192-162(181)182)136(251)224-122(79(4)5)151(266)213-103(64-115(165)232)126(241)194-67-118(235)196-81(7)124(239)199-89(30-16-50-185-155(167)168)131(246)211-102(63-86-42-46-88(231)47-43-86)141(256)225-121(78(2)3)150(265)207-95(36-22-56-191-161(179)180)134(249)218-112(76-275)148(263)220-111(75-274)147(262)216-107(71-229)142(257)203-92(33-19-53-188-158(173)174)130(245)208-98(154(269)270)38-24-58-193-163(183)184;3-2(4,5)1(6)7/h10-15,26-29,40-47,78-82,89-114,121-123,227-231,271-276H,9,16-25,30-39,48-77,164H2,1-8H3,(H2,165,232)(H2,166,233)(H,194,241)(H,195,242)(H,196,235)(H,197,259)(H,198,236)(H,199,239)(H,200,244)(H,201,243)(H,202,250)(H,203,257)(H,204,260)(H,205,261)(H,206,258)(H,207,265)(H,208,245)(H,209,248)(H,210,247)(H,211,246)(H,212,264)(H,213,266)(H,214,253)(H,215,255)(H,216,262)(H,217,240)(H,218,249)(H,219,252)(H,220,263)(H,221,267)(H,222,254)(H,223,234)(H,224,251)(H,225,256)(H,237,238)(H,269,270)(H4,167,168,185)(H4,169,170,186)(H4,171,172,187)(H4,173,174,188)(H4,175,176,189)(H4,177,178,190)(H4,179,180,191)(H4,181,182,192)(H4,183,184,193);(H,6,7)/t80-,81-,82-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,121-,122-,123-;/m0./s1
InChi Key
BVFNLWWBUSGIFS-SROLMOCTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Defensin NP-3A (60-93) is an a-defensin peptide cleaved from a defensin precursor protein and secreted by granulocytes and involved in antimicrobial and immunomodulatory responses.1,2 It is active against C. albicans when used at a concentration of 10 µg/ml. Defensin NP-3A (60-93), in combination with NP-1, NP-2, NP-3B, NP-4, and NP-5, induces leakage of high molecular weight dextrans and low molecular weight reporters in E. coli membrane mimics.3 It inhibits phagocytosis in primary mouse macrophages in a concentration-dependent manner.4 Defensin NP-3A (60-93) induces histamine secretion in primary rat mast cells (EC50 = 70 nM).5 It inhibits corticotropin-induced corticosterone production but does not decrease basal corticosterone levels in primary rat adrenal cells (IC50 = 33 pM).6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Selsted, M.E., Szklarek, D., Ganz, T., et al. Activity of rabbit leukocyte peptides against Candida albicans. Infect. Immun. 49(1), 202-206 (1985).

    2. Ganz, T., Selsted, M.E., and Lehrer, R.I. Defensins. Eur. J. Haematol. 44(1), 1-8 (1990).

    3. Hristova, K., Selsted, M.E., and White, S.H. Critical role of lipid composition in membrane permeabilization by rabbit neutrophil defensins. The Journal of Biological Chemisty 272(39), 24224-24233 (1997).

    4. Ichinose, M., and Sawada, M. A flow cytometric assay reveals a suppression of phagocytosis by rabbit defensin NP-3A in mouse peritoneal macrophages. Microbiol. Immunol. 39(5), 365-367 (1995).

    5. Befus, A.D., Mowat, C., Gilchrist, M., et al. Neutrophil defensins induce histamine secretion from mast cells: Mechanisms of action. J. Immunol. 163(2), 947-953 (1999).

    6. Zhu, Q.Z., Hu, J., Mulay, S., et al. Isolation and structure of corticostatin peptides from rabbit fetal and adult lung. Proc. Natl. Acad. Sci. USA 85(2), 592-596 (1988).