An NFATc1 inhibitor
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NFATc1 Inhibitor A04

Item No. 41521

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-fluoro-N-(2-fluoro-4-iodophenyl)-2-hydroxy-benzamide
CAS Number
1912422-56-0
Synonyms
  • Nuclear Factor of Activated T cells c1 Inhibitor A04
Molecular Formula
C13H8F2INO2
Formula Weight
375.1
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
FC1=CC=C(O)C(C(NC2=CC=C(C=C2F)I)=O)=C1
InChi Code
InChI=1S/C13H8F2INO2/c14-7-1-4-12(18)9(5-7)13(19)17-11-3-2-8(16)6-10(11)15/h1-6,18H,(H,17,19)
InChi Key
IGRCFOGPIJEESA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $50

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    10 mg

    $95

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    50 mg

    $323

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    100 mg

    $495

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    Product Description

    NFATc1 inhibitor A04 is an inhibitor of nuclear factor of activated T cells c1 (NFATc1).1 It inhibits RANKL-induced nuclear translocation of NFATc1 in RAW 264.7 cells when used at concentrations of 1.5 or 2 µM. NFATc1 inhibitor A04 reduces RANKL-induced differentiation of RAW 264.7 cells into osteoclasts (IC50 = 1.57 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, C.L., Lee, C.C., Liu, F.L., et al. Design, synthesis and SARs of novel salicylanilides as potent inhibitors of RANKL-induced osteoclastogenesis and bone resorption. Eur. J. Med. Chem. 117, 70-84 (2016).