A Nampt activator
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SBI-797812

Item No. 41526

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-(8-oxa-3-azabicyclo[3.2.1]oct-3-ylsulfonyl)phenyl]-N′-(4-pyridinylmethyl)-urea
CAS Number
2237268-08-3
Molecular Formula
C19H22N4O4S
Formula Weight
402.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(NCC1=CC=NC=C1)NC2=CC=C(S(=O)(N3CC4OC(CC4)C3)=O)C=C2
InChi Code
InChI=1S/C19H22N4O4S/c24-19(21-11-14-7-9-20-10-8-14)22-15-1-5-18(6-2-15)28(25,26)23-12-16-3-4-17(13-23)27-16/h1-2,5-10,16-17H,3-4,11-13H2,(H2,21,22,24)
InChi Key
KTSOHNHLOLGQCY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $87

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    10 mg

    $165

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    25 mg

    $392

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    50 mg

    $653

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    Product Description

    SBI-797812 is an activator of nicotinamide phosphoribosyltransferase (Nampt).1 It increases nicotinamide (NMN) levels and prevents NAD+ feedback inhibition in a cell-free assay using recombinant human Nampt when used at a concentration of 2 µM. In vivo, SBI-797812 (20 mg/kg) increases liver levels of NAD+ but does not affect NAD+ levels in the heart, quadriceps, or gastrocnemius in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gardell, S.J., Hopf, M., Khan, A., et al. Boosting NAD+ with a small molecule that activates NAMPT. Nat. Commun. 10(1), 3241 (2019).