A Gram-negative-selective antibiotic
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Lolamicin

Item No. 41528

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[3-[4-(2,6-dimethyl-4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-benzonitrile
CAS Number
2930690-12-1
Molecular Formula
C24H20N4O
Formula Weight
380.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Soluble: ≥ 10 mg/ml
SMILES
N#CC1=CC=CC(COC2=CC=CC(C3=NNC=C3C4=CC(C)=NC(C)=C4)=C2)=C1
InChi Code
InChI=1S/C24H20N4O/c1-16-9-21(10-17(2)27-16)23-14-26-28-24(23)20-7-4-8-22(12-20)29-15-19-6-3-5-18(11-19)13-25/h3-12,14H,15H2,1-2H3,(H,26,28)
InChi Key
CIXIQLLJOWEAKU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Lolamicin is a Gram-negative-selective antibiotic.1 It is selective for Gram-negative pathogenic bacteria, such as E. coli, S. typhimurium, and E. cloacae (MICs = 0.008-8 µg/ml), over Gram-negative commensal bacteria and Gram-positive pathogenic and commensal bacteria (MICs = >128 µg/ml). Lolamicin is also active against multidrug-resistant clinical isolates of E. coli, K. pneumoniae, and E. cloacae. Lolamicin-resistant bacteria contain mutations in LolC and LolE, which encode subunits of the LolCDE lipoprotein transport system. In vivo, lolamicin (100 mg/kg) increases survival and decreases lung colony-forming units (CFUs) in multiple mouse models of septicemia and pneumonia, respectively. It also does not affect fecal bacterial taxonomic composition in healthy mice nor allow C. difficile colonization in C. difficile-challenged mice when administered at a dose of 200 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Muñoz, K.A., Ulrich, R.J., Vasan, A.K., et al. A Gram-negative-selective antibiotic that spares the gut microbiome. Nature 630(8016), 429-436 (2024).