A prolyl endopeptidase inhibitor
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Z-Prolyl-prolinal

Item No. 41535

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-2-[[(2S)-2-formyl-1-pyrrolidinyl]carbonyl]-1-pyrrolidinecarboxylic acid, 1,1-dimethylethyl ester
CAS Number
86925-97-5
Synonyms
  • Benzyloxycarbonyl-prolyl-prolinal
  • ZPP
Molecular Formula
C15H24N2O4
Formula Weight
296.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
CC(C)(C)OC(N1CCC[C@H]1C(N2CCC[C@H]2C=O)=O)=O
InChi Code
InChI=1S/C15H24N2O4/c1-15(2,3)21-14(20)17-9-5-7-12(17)13(19)16-8-4-6-11(16)10-18/h10-12H,4-9H2,1-3H3/t11-,12-/m0/s1
InChi Key
CTCMMWKUMNGTPE-RYUDHWBXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $180

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    25 mg

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    Product Description

    Z-Prolyl-prolinal (ZPP) is an inhibitor of prolyl endopeptidase (Kis = 0.35 and 0.5 nM for the mouse and human enzymes, respectively).1 ZPP (4 and 40 µM) inhibits the formation of angiotensin (1-7) from angiotensin II in kidney sections isolated from wild-type and Ace2-/- mice.2 In vivo, ZPP (10 and 50 mg/kg) reduces hippocampal neuronal cell death in a rat model of global ischemia.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bakker, A.V., Jung, S., Spencer, R.W., et al. Slow tight-binding inhibition of prolyl endopeptidase by benzyloxycarbonyl-prolyl-prolinal. Biochem. J. 271(2), 559-562 (1990).

    2. Grobe, N., Weir, N.M., Leiva, O., et al. Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry. Am. J. Physiol. Cell Physiol. 304(10), C945-C953 (2013).

    3. Shishido, Y., Furushiro, M., Tanabe, S., et al. Effects of prolyl endopeptidase inhibitors and neuropeptides on delayed neuronal death in rats. Eur. J. Pharmacol. 372(2), 135-142 (1999).