A cationic sulfonium lipid
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DOSEH (chloride)

Item No. 41601

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2-hydroxyethyl)dioctadecylsulfonium, monochloride
Molecular Formula
C38H79OS • Cl
Formula Weight
619.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlChloroform: Slightly soluble: 0.1-1 mg/ml
SMILES
CCCCCCCCCCCCCCCCCC[S+](CCO)CCCCCCCCCCCCCCCCCC.[Cl-]
InChi Code
InChI=1S/C38H79OS.ClH/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-36-40(38-35-39)37-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h39H,3-38H2,1-2H3;1H/q+1;/p-1
InChi Key
WQRANVYEXIQCJE-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $141

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    10 mg

    $253

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    25 mg

    $599

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    Product Description

    DOSEH is a cationic sulfonium lipid that has been used in the generation of sulfonium lipid nanoparticles (sLNPs) for the delivery of mRNA in vivo.1 LNPs containing DOSEH and encapsulating an mRNA reporter accumulate primarily in the lungs after intravenous administration in mice. DOSEH-containing LNPs encapsulating Cre mRNA induce the expression of tdTomato in the lungs of Ai14 mice engineered to express tdTomato upon Cre-mediated recombination.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Popoola, D.O., Cao, Z., Men, Y., et al. Lung-specific mRNA delivery enabled by sulfonium lipid nanoparticles. Nano Lett. 24(26), 8080-8088 (2024).