A tricyclic antidepressant
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Iprindole

Item No. 41664

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,7,8,9,10,11-hexahydro-N,N-dimethyl-5H-cyclooct[b]indole-5-propanamine
CAS Number
5560-72-5
Synonyms
  • NSC 169449
Molecular Formula
C19H28N2
Formula Weight
284.4
Purity
≥95%
Formulation (Request formulation change)
A solution in ethanol
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
CN(C)CCCN1C(CCCCCC2)=C2C3=C1C=CC=C3
InChi Code
InChI=1S/C19H28N2/c1-20(2)14-9-15-21-18-12-6-4-3-5-10-16(18)17-11-7-8-13-19(17)21/h7-8,11,13H,3-6,9-10,12,14-15H2,1-2H3
InChi Key
PLIGPBGDXASWPX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $58

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    10 mg

    $104

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    25 mg

    $215

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    Product Description

    Iprindole is a tricyclic antidepressant.1,2 It binds to the serotonin (5-HT) receptor subtypes 5-HT2A and 5-HT2C in radioligand binding assays (Kis = 0.217 and 0.206 µM, respectively) but only weakly inhibits norepinephrine (NE) and 5-HT uptake in mouse brain slices (IC50s = 9 and 50 µM, respectively).1,3 Iprindole reduces immobility in the forced swim test in rats when administered at a dose of 10 mg/kg once per day for 21 days.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ross, S.B., Renyi, A.L., and Ogren, S.O. A comparison of the inhibitory activities of iprindole and imipramine on the uptake of 5-hydroxytryptamine and noradrenaline in brain slices. Life Sci. 10(22), 1267-1277 (1971).

    2. Berettera, C., Invernizzi, R.W., Pulvirenti, L., et al. Chronic treatment with iprindole reduces immobility of rats in the behavioural “despair” test by activating dopaminergic mechanisms in the brain. J. Pharm. Pharmacol. 38(4), 313-315 (1986).

    3. Pälvimäki, E.P., Roth, B.L., Majasuo, H., et al. Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2C receptor. Psychopharmacology (Berl) 126(3), 234-240 (1996).