A HIF-2α agonist
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ZG-2033

Item No. 41672

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3,5-dimethoxyphenyl)-1,2-benzisothiazol-3-amine
CAS Number
2685739-28-8
Molecular Formula
C15H14N2O2S
Formula Weight
286.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
COC1=CC(OC)=CC(NC2=NSC3=CC=CC=C32)=C1
InChi Code
InChI=1S/C15H14N2O2S/c1-18-11-7-10(8-12(9-11)19-2)16-15-13-5-3-4-6-14(13)20-17-15/h3-9H,1-2H3,(H,16,17)
InChi Key
VITJWQGYLIMHDA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $171

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    1 mg

    $325

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    5 mg

    $768

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    10 mg

    $1,023

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    Product Description

    ZG-2033 is an agonist of hypoxia-inducible factor 2α (HIF-2α).1 It induces HIF-2α transcriptional activity in a reporter assay using 786-O cells expressing HIF-2α (EC50 = 0.49 µM). ZG-2033 (10 or 50 µM), in combination with the inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) and HIF-PH3 AKB-6548 (vadadustat; Item No. 15295), increases the number of erythrocytes in a zebrafish model of doxorubicin-induced anemia. It increases the plasma levels of erythropoietin (EPO) in mice when administered at concentrations of 100 or 200 mg/kg in combination with vadadustat.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yu, Y., Yang, F., Yu, Q., et al. Discovery of a potent and orally bioavailable hypoxia-inducible factor 2α (HIF-2α) agonist and its synergistic therapy with prolyl hydroxylase inhibitors for the treatment of renal anemia. J. Med. Chem. 64(23), 17384-17402 (2021).