A surrogate agonist of GPR27
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CID-5157334

Item No. 41677

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4-dichloro-N-[4-[(phenylamino)sulfonyl]phenyl]-benzamide
CAS Number
651295-98-6
Synonyms
  • CID-5128535
Molecular Formula
C19H14Cl2N2O3S
Formula Weight
421.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
ClC(C=C1Cl)=CC=C1C(NC(C=C2)=CC=C2S(NC3=CC=CC=C3)(=O)=O)=O
InChi Code
InChI=1S/C19H14Cl2N2O3S/c20-13-6-11-17(18(21)12-13)19(24)22-14-7-9-16(10-8-14)27(25,26)23-15-4-2-1-3-5-15/h1-12,23H,(H,22,24)
InChi Key
LNUTUGZHBGDTOU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    CID-5157334 is a surrogate agonist of G protein-coupled receptor 27 (GPR27).1 It induces recruitment of β-arrestin-2 in complementation assays using wild-type GPR27 or a GPR27-vasopressin 2 (GPR27V2) chimeric receptor (EC50s = 7.943 and 0.417 nM, respectively) but does not induce recruitment of β-arrestin-1 in the same assay or activation of the Gq, Gs, or Gi signaling pathways in aequorin-GFP assays. CID-5157334 is selective for GPR27 over GPR85V2 and GPR173V2 chimeric receptors at 15 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dupuis, N., Laschet, C., Franssen, D., et al. Activation of the orphan G protein-coupled receptor GPR27 by surrogate ligands promotes β-arrestin 2 recruitment. Mol. Pharmacol. 91(6), 595-608 (2017).