An inhibitor of WRN
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Werner Syndrome RecQ Helicase-IN-2

Item No. 41678

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3,6-dihydro-2H-pyran-4-yl)-5-ethyl-6-[4-[(5-hydroxy-6-methyl-4-pyrimidinyl)carbonyl]-1-piperazinyl]-N-[2-methyl-4-(trifluoromethyl)phenyl]-7-oxo-[1,2,4]triazolo[1,5-a]pyrimidine-4(7H)-acetamide
CAS Number
2869954-51-6
Synonyms
  • Werner Syndrome RecQ Helicase Inhibitor 2
  • WS RecQ Helicase-IN-2
  • WS RecQ Helicase Inhibitor 2
Molecular Formula
C32H34F3N9O5
Formula Weight
681.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
CC1=CC(C(F)(F)F)=CC=C1NC(CN(C2=NC(C3=CCOCC3)=NN24)C(CC)=C(N5CCN(C(C6=NC=NC(C)=C6O)=O)CC5)C4=O)=O
InChi Code
InChI=1S/C32H34F3N9O5/c1-4-23-26(41-9-11-42(12-10-41)29(47)25-27(46)19(3)36-17-37-25)30(48)44-31(39-28(40-44)20-7-13-49-14-8-20)43(23)16-24(45)38-22-6-5-21(15-18(22)2)32(33,34)35/h5-7,15,17,46H,4,8-14,16H2,1-3H3,(H,38,45)
InChi Key
FHYSHYIPBJMLRM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $109

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    5 mg

    $491

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    10 mg

    $872

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    50 mg

    $3,267

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    Cayman Chemical
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    Product Description

    Werner syndrome RecQ helicase-IN-2 is an inhibitor of the DNA helicase Werner syndrome protein (WRN; IC50 = 100 nM).1 It selectively inhibits the growth of SW48 colorectal cancer cells over DLD-1 colorectal cancer cells lacking WRN (DLD-1-WRN-KO; GI50s = 100 and >10,000 nM, respectively). Werner syndrome RecQ helicase-IN-2 (120 mg/kg per day) reduces tumor volume in an SW48 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bordas, V., Brun, J., Decker, A., et al. Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of Werner syndrome RecQ helicase (WRN). (2022).