An LPA1 agonist
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UCM-05194 (ammonium salt)

Item No. 41682

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
benzenedecanoic acid, (1S)-1-(bromomethyl)-2-(phosphonooxy)ethyl ester, monoammonium salt
Molecular Formula
C19H29BrO6P • NH4
Formula Weight
482.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: Slightly solubleWater: Soluble
SMILES
O=C(CCCCCCCCCC1=CC=CC=C1)O[C@@H](COP(O)([O-])=O)CBr.[NH4+]
InChi Code
InChI=1S/C19H30BrO6P.H3N/c20-15-18(16-25-27(22,23)24)26-19(21)14-10-5-3-1-2-4-7-11-17-12-8-6-9-13-17;/h6,8-9,12-13,18H,1-5,7,10-11,14-16H2,(H2,22,23,24);1H3/t18-;/m1./s1
InChi Key
UKZAXCXBQFDZCW-GMUIIQOCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $105

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    5 mg

    $471

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    Product Description

    UCM-05194 is an agonist of lysophosphatidic acid receptor 1 (LPA1).1 It induces calcium mobilization in RH7777 cells expressing LPA1 (EC50 = 0.24 µM). It is selective for LPA1 over LPA2 and LPA3 at 10 µM and is 10-fold selective over LPA5 and 50-fold selective over LPA4, LPA6, and autotaxin. UCM-05194 (1 µM) induces neurite retraction in, and migration of, B103 rat neuroblastoma cells overexpressing LPA1. It induces receptor internalization and neuronal desensitization in the same cells when used at a concentration of 1 µM and reduces the firing activity of primary rat neonatal dorsal root ganglia (DRG) neurons with repeated application at 10 µM. UCM-05194 (10 mg/kg) reduces acetic acid-induced writhing and hind paw mechanical hypersensitivity in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. González-Gil, I., Zian, D., Vázquez-Villa, H., et al. A novel agonist of the type 1 lysophosphatidic acid receptor (LPA1), UCM-05194, shows efficacy in neuropathic pain amelioration. J. Med. Chem. 63(5), 2372-2390 (2020).