A derivative of exatecan and a cytotoxic agent in ADCs
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Dxd

Item No. 41699

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-1-yl]-2-hydroxy-acetamide
CAS Number
1599440-33-1
Molecular Formula
C26H24FN3O6
Formula Weight
493.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
OCC(N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62)=O
InChi Code
InChI=1S/C26H24FN3O6/c1-3-26(35)15-6-19-23-13(8-30(19)24(33)14(15)10-36-25(26)34)22-17(28-20(32)9-31)5-4-12-11(2)16(27)7-18(29-23)21(12)22/h6-7,17,31,35H,3-5,8-10H2,1-2H3,(H,28,32)/t17-,26-/m0/s1
InChi Key
PLXLYXLUCNZSAA-QLXKLKPCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $72

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    25 mg

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    50 mg

    $304

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    100 mg

    $429

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    Cayman Chemical
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    Product Description

    Dxd is a derivative of the DNA topoisomerase I inhibitor exatecan (Item No. 35452) and a cytotoxic agent that has been used in the synthesis of antibody-drug conjugates (ADCs).1 It has been used in the synthesis of ADCs targeting HER2 with anticancer activity in vitro and in vivo.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Conilh, L., Fournet, G., Fourmaux, E., et al. Exatecan antibody drug conjugates based on a hydrophilic polysarcosine drug-linker platform. Pharmaceuticals (Basel) 14(3), 247 (2021).