A fluorescent probe for mitochondrial lipid peroxides
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MitoPeDPP

Item No. 41727

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[3-[4-(3-perylenylphenylphosphino)phenoxy]propyl]triphenyl-phosphonium, monoiodide
CAS Number
1187472-58-7
Molecular Formula
C53H41OP2 • I
Formula Weight
882.8
Purity
≥80%
Emission
470 nm
Excitation
452 nm
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleMethanol: Soluble
SMILES
C12=CC=CC3=C1C(C4=CC=CC5=C4C3=CC=C5P(C6=CC=C(OCCC[P+](C7=CC=CC=C7)(C8=CC=CC=C8)C9=CC=CC=C9)C=C6)C%10=CC=CC=C%10)=CC=C2.[I-]
InChi Code
InChI=1S/C53H41OP2.HI/c1-5-19-41(20-6-1)55(51-36-35-49-47-28-14-18-39-17-13-27-46(52(39)47)48-29-15-30-50(51)53(48)49)42-33-31-40(32-34-42)54-37-16-38-56(43-21-7-2-8-22-43,44-23-9-3-10-24-44)45-25-11-4-12-26-45;/h1-15,17-36H,16,37-38H2;1H/q+1;/p-1
InChi Key
OLKPFCYMHIHKMF-UHFFFAOYSA-M
Shipping & Storage Information
Storage
4°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 µg x 3

    $281

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    Product Description

    MitoPeDPP is a cell-permeable fluorescent probe for mitochondrial lipid peroxides. It is selective for tert-butyl hydroperoxide (t-BHP) over hydrogen peroxide, superoxide, nitric oxide, and peroxynitrite. Upon reaction with lipid peroxides, MitoPeDPP is oxidized and displays an emission at 470 nm upon excitation at 452 nm.1 Monitoring lipid peroxidation has high relevance to various cellular processes, especially ferroptosis, which is an iron-dependent cell death characterized by increased lipid peroxidation.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakamura, S., Nakanishi, A., Takazawa, M., et al. Ionomycin-induced calcium influx induces neurite degeneration in mouse neuroblastoma cells: Analysis of a time-lapse live cell imaging system. Free Radic. Res. 50(11), 1214-1225 (2016).

    2. Angeli, J.P.F., Miyamoto, S., and Schulze, A. Ferroptosis: The greasy side of cell death. Chem. Res. Toxicol. 32, 362-369 (2019).

    3. Yang, W.S., and Stockwell, B.R. Ferroptosis: Death by lipid peroxidation. Trends Cell Biol. 26(3), 165-176 (2016).