An aldose reductase inhibitor
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Imirestat

Item No. 41829

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,7-difluoro-spiro[9H-fluorene-9,4′-imidazolidine]-2′,5′-dione
CAS Number
89391-50-4
Synonyms
  • AL 01576
  • Alcon 1576
  • HOE 843
Molecular Formula
C15H8F2N2O2
Formula Weight
286.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
FC1=CC=C(C2=C3C=C(F)C=C2)C(C3(C(N4)=O)NC4=O)=C1
InChi Code
InChI=1S/C15H8F2N2O2/c16-7-1-3-9-10-4-2-8(17)6-12(10)15(11(9)5-7)13(20)18-14(21)19-15/h1-6H,(H2,18,19,20,21)
InChi Key
QCCHBHSAIQIQGO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    $325

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    10 mg

    $546

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    25 mg

    $939

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    Cayman Chemical
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    Product Description

    Imirestat is an inhibitor of aldose reductase (IC50s = 24 and 18 nM for the rat and human enzymes, respectively).1 It reduces periodontal bone loss in a rat model of P. gingivalis LPS-induced periodontal inflammation and bone reabsorption when administered in the diet at 0.0125% (w/w).2 Dietary administration of imirestat (0.0125% w/w) decreases the incidence and severity of cataracts in a rat model of streptozotocin-induced diabetes.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Griffin, B.W., McNatt, L.G., Chandler, M.L., et al. Effects of two new aldose reductase inhibitors, AL-1567 and AL-1576, in diabetic rats. Metabolism 36(5), 486-490 (1987).

    2. Kador, P.F., O'Meara, J.D., Blessing, K., et al. Efficacy of structurally diverse aldose reductase inhibitors on experimental periodontitis in rats. J. Periodontol. 82(6), 926-933 (2011).

    3. Kador, P.F., Lee, J.W., Fujisawa, S., et al. Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats. J. Ocul. Pharmacol. Ther. 16(2), 149-160 (2000).