A partial agonist of α7 nAChR
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AQW-051

Item No. 41851

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R)-3-[[6-(4-methylphenyl)-3-pyridinyl]oxy]-1-azabicyclo[2.2.2]octane
CAS Number
669770-29-0
Synonyms
  • VQW-765
Molecular Formula
C19H22N2O
Formula Weight
294.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
CC(C=C1)=CC=C1C2=NC=C(C=C2)O[C@@H]3C4CCN(CC4)C3
InChi Code
InChI=1S/C19H22N2O/c1-14-2-4-15(5-3-14)18-7-6-17(12-20-18)22-19-13-21-10-8-16(19)9-11-21/h2-7,12,16,19H,8-11,13H2,1H3/t19-/m0/s1
InChi Key
NPDLTEZXGWRMLQ-IBGZPJMESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $74

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    10 mg

    $134

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    25 mg

    $295

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    50 mg

    $443

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    Product Description

    AQW-051 is a partial agonist of the α7 nicotinic acetylcholine receptor (nAChR).1 It induces calcium influx in GH3 cells expressing α7 nAChR (EC50 = 38.9 nM). AQW-051 (0.03 or 0.3 mg/kg) improves learning and memory in the social recognition test in mice. It improves learning and memory in the Morris water maze test in rats when administered at a dose of 3 mg/kg. AQW-051 (2, 8, or 15 mg/kg per day) increases the duration of response to L-DOPA-induced increases in coordination in an ovariectomized cynomolgus monkey model of MPTP-induced Parkinson's disease.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Feuerbach, D., Pezous, N., Weiss, M., et al. AQW051, a novel, potent and selective α7 nicotinic ACh receptor partial agonist: Pharmacological characterization and phase I evaluation. Br. J. Pharmacol. 172(5), (2015).

    2. Di Paolo, T., Grégoire, L., Feuerbach, D., et al. AQW051, a novel and selective nicotinic acetylcholine receptor α7 partial agonist, reduces ʟ-Dopa-induced dyskinesias and extends the duration of ʟ-Dopa effects in parkinsonian monkeys. Parkinsonism Relat. Disord. 20(11), 1119-1123 (2014).