A covalent inhibitor of K-RasG12C
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GDC-6036

Item No. 41852

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]-2-propen-1-one
CAS Number
2417987-45-0
Synonyms
  • Divarasib
  • RG-6330
Molecular Formula
C29H32ClF4N7O2
Formula Weight
622.1
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
CN(CCC1)C1COC2=NC(N3C(C)CN(C(C=C)=O)CC3)=C(C=C(C(C4=C(C(F)(F)F)C(C)=CC(N)=N4)=C5F)Cl)C5=N2
InChi Code
InChI=1S/C29H32ClF4N7O2/c1-5-21(42)40-9-10-41(16(3)13-40)27-18-12-19(30)22(26-23(29(32,33)34)15(2)11-20(35)36-26)24(31)25(18)37-28(38-27)43-14-17-7-6-8-39(17)4/h5,11-12,16-17H,1,6-10,13-14H2,2-4H3,(H2,35,36)
InChi Key
ZRBPIAWWRPFDPY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    5 mg

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    10 mg

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    Cayman Chemical
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    Product Description

    GDC-6036 is a covalent inhibitor of K-Ras containing a glycine-to-cysteine substitution at position 12 (K-RasG12C).1 It decreases tumor volume in a PaCa-2 pancreatic cancer mouse xenograft model when administered at doses ranging from 1 to 100 mg/kg per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tran, J.C., Hunsaker, T., Bell, C., et al. Quantifying KRAS G12C covalent drug inhibitor activity in mouse tumors using mass spectrometry. Anal. Chem. 95(11), 4834-4839 (2023).