A neuroprotective agent and prodrug form of galantamine
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Active Metabolite(s)
17559Galantamine 35247Galantamine (hydrobromide)
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GLN-1062

Item No. 41855

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4aS,6R,8aS)-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6-benzoate
CAS Number
224169-27-1
Synonyms
  • Benzgalantamine
Molecular Formula
C24H25NO4
Formula Weight
391.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
COC1=C2C3=C(C=C1)CN(C)CC[C@@]34[C@@](C[C@H](C=C4)OC(C5=CC=CC=C5)=O)([H])O2
InChi Code
InChI=1S/C24H25NO4/c1-25-13-12-24-11-10-18(28-23(26)16-6-4-3-5-7-16)14-20(24)29-22-19(27-2)9-8-17(15-25)21(22)24/h3-11,18,20H,12-15H2,1-2H3/t18-,20-,24-/m0/s1
InChi Key
JKVNJTYHRABHIY-WXVUKLJWSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $138

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    10 mg

    $270

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    50 mg

    $781

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    100 mg

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    Cayman Chemical
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    Product Description

    GLN-1062 is a neuroprotective agent and prodrug form of galantamine (Item Nos. 17559 | 35247), an alkaloid with acetylcholine esterase (AChE) inhibitory and nicotinic acetylcholine (nAChR) potentiating activities.1 It also is active against M. tuberculosis and M. aurum (MIC = 31.25 µg/ml for both).2 GLN-1062 decreases the frequency of spontaneous alternations induced by the alkaloid scopolamine (Item No. 40307) in the T maze continuous alternation task in mice (ED50 = 0.34 mg/kg).1 It inhibits increases in hippocampal and entorhinal cortex amyloid-β (Aβ) plaque densities in the 5XFAD transgenic mouse model of Alzheimer's disease when administered intranasally at a dose of 6 mg/kg per day.3 Formulations containing GLN-1062 have been used in the treatment of Alzheimer's disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Maelicke, A., Hoeffle-Maas, A., Ludwig, J., et al. Memogain is a galantamine pro-drug having dramatically reduced adverse effects and enhanced efficacy. J. Mol. Neurosci. 40(1-2), 135-137 (2010).

    2. Maafi, N., Mamun, A.A., Janďourek, O., et al. Semisynthetic derivatives of selected amaryllidaceae alkaloids as a new class of antimycobacterial agents. Molecules 26(19), 6023 (2021).

    3. Bhattacharya, S., and Montag, D. Acetylcholinesterase inhibitor modifications: a promising strategy to delay the progression of Alzheimer’s disease. Neural. Regen. Res. 10(1), 43-45 (2015).