A LANCL2 pathway activator
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BT-11

Item No. 41856

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1′-(1,4-piperazinediyl)bis[1-[6-(1H-benzimidazol-2-yl)-2-pyridinyl]-methanone
CAS Number
1912399-75-7
Molecular Formula
C30H24N8O2
Formula Weight
528.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C(N1CCN(C(C2=CC=CC(C3=NC4=CC=CC=C4N3)=N2)=O)CC1)C5=CC=CC(C6=NC7=CC=CC=C7N6)=N5
InChi Code
InChI=1S/C30H24N8O2/c39-29(25-13-5-11-23(31-25)27-33-19-7-1-2-8-20(19)34-27)37-15-17-38(18-16-37)30(40)26-14-6-12-24(32-26)28-35-21-9-3-4-10-22(21)36-28/h1-14H,15-18H2,(H,33,34)(H,35,36)
InChi Key
MVHWZNBAQIGPOQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $149

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    10 mg

    $268

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    25 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    BT-11 is an activator of the lanthionine synthetase C-like 2 (LANCL2) pathway.1 It binds to LANCL2 with a Kd value of 7.7 µM and increases cAMP levels in mouse splenocytes isolated from wild-type, but not Lancl2-/-, mice when used at concentrations of 5 and 10 µM. BT-11 (8 mg/kg) reduces leukocyte infiltration, epithelial erosion, and mucosal thickening in the colon in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250). It reduces the percentage of Tnf-α+ CD45+ cells and MHC-II+ CD11c+ granulocytes and increases the percentage of Il-10+ CD45+ cells isolated from wild-type mice in a model of DSS-induced colitis but has no effect on these parameters in Lancl2-/- mice. BT-11 also reduces histopathological changes in wild-type mice in a model of DSS-induced colitis but not in mice with a T cell-specific conditional knockout of Lancl2.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Carbo, A., Gandour, R.D., Hontecillas, R., et al. An N,N-bis(benzimidazolylpicolinoyl)piperazine (BT-11): A novel lanthionine synthetase C-like 2-based therapeutic for inflammatory bowel disease. J. Med. Chem. 59(22), 10113-10126 (2016).

    2. Leber, A., Hontecillas, R., Zoccoli-Rodriguez, V., et al. Activation of LANCL2 by BT-11 ameliorates IBD by supporting regulatory T cell stability through immunometabolic mechanisms. Inflamm. Bowel Dis. 24(9), 1978-1991 (2018).