An inhibitor of FAP
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SP-13786

Item No. 41857

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-4-quinolinecarboxamide
CAS Number
1448440-52-5
Synonyms
  • UAMC-1110
Molecular Formula
C17H14F2N4O2
Formula Weight
344.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(N1CC(F)(F)C[C@H]1C#N)CNC(C2=CC=NC3=C2C=CC=C3)=O
InChi Code
InChI=1S/C17H14F2N4O2/c18-17(19)7-11(8-20)23(10-17)15(24)9-22-16(25)13-5-6-21-14-4-2-1-3-12(13)14/h1-6,11H,7,9-10H2,(H,22,25)/t11-/m0/s1
InChi Key
PUOOCZVRHBHJRS-NSHDSACASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $102

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    10 mg

    $152

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    25 mg

    $253

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    100 mg

    $810

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    Product Description

    SP-13786 is an inhibitor of the protease fibroblast activation protein (FAP; IC50 = 3.2 nM).1 It is selective for FAP over prolyl endopeptidase, dipeptidyl peptidase 4 (DPP-4), DPP-9, and DPP-2 (IC50s = >1.8, >100, >12.5, and >100 µM, respectively). Nanoliposomes containing a PEGylated form of SP-13786 have been used to target cancer-associated fibroblasts (CAFs) in vitro and in vivo.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jansen, K., Heirbaut, L., Verkerk, R., et al. Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP). J. Med. Chem. 57(7), 3053-3074 (2014).

    2. Kong, L., Yu, Y., Yang, R., et al. Development and efficacy evaluation of nanoliposomes targeting CAFs-LCSCs communication for hepatocellular carcinoma treatment. Chem. Eng. J. 496, 154173 (2024).