A purported binding agent of filamin A
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PTI-125 (hydrochloride)

Item No. 41859

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-methyl-1-(phenylmethyl)-1,4,8-triazaspiro[4.5]decan-2-one, dihydrochloride
CAS Number
2480226-06-8
Molecular Formula
C15H21N3O • 2HCl
Formula Weight
332.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
CN1CCC(NCC2=O)(N2CC3=CC=CC=C3)CC1.Cl.Cl
InChi Code
InChI=1S/C15H21N3O.2ClH/c1-17-9-7-15(8-10-17)16-11-14(19)18(15)12-13-5-3-2-4-6-13;;/h2-6,16H,7-12H2,1H3;2*1H
InChi Key
IZIPGYSLPYPJDQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $182

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    10 mg

    $346

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    50 mg

    $999

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    100 mg

    $1,271

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    Product Description

    PTI-125 is a purported binding agent of filamin A, a cytoskeletal protein said to stabilize the interaction between amyloid-β (1-42) (Aβ42) and the α7 nicotinic acetylcholine receptor (nAChR).1,2 PTI-125 reportedly binds to filamin A to reverse an aberrant conformational change induced by Aβ42, which prevents and reverses Aβ42-α7 nAChR binding and improves neuropathological outcomes in the 3xTg mouse model of Alzheimer’s disease. However, the data regarding PTI-125 have prompted expressions of concern by the journals in which the data were published.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1.  Expression of concern: Wang et al., "Reducing amyloid-related alzheimer’s disease pathogenesis by a small molecule targeting filamin A". J. Neurosci. 42(3), 529 (2022).

    2. Wang, H.Y., Lee, K.C., Pei, Z., et al. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer’s disease pathogenesis. Neurobiol. Aging 55, 99-114 (2017).