2-TEDC

2-TEDC is a lipoxygenase (LO) inhibitor (IC₅₀s = 0.09, 0.013, and 0.5 µM for 5-, 12-, and 15-LO, respectively).¹ It prevents axon degeneration induced by withdrawal of nerve growth factor (NGF) in primary rat dorsal root ganglion neurons (mean EC₅₀ = 2.79 µM).² 2-TEDC also inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp; IC₅₀ = 7.99 µM) and reduces major capsid protein levels and virus titers in grouper spleen cells infected with Singapore grouper iridovirus when used at a concentration of 12.5 µM.^3,4

WARNING This product is not for human or veterinary use.

1. Cho, H., Ueda, M., Tamaoka, M., et al. Novel caffeic acid derivatives: Extremely potent inhibitors of 12-lipoxygenase. J. Med. Chem. 34(4), 1503-1505 (1991).

2. Rudhard, Y., Ghosh, A.S., Lippert, B., et al. Identification of 12/15-lipoxygenase as a regulator of axon degeneration through high-content screening. J. Neurosci. 35(7), 2927-2941 (2015).

3. Kuzikov, M., Reinshagen, J., Wycisk, K., et al. Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex. Virus Res. 343, 199356 (2024).

4. Ni, N., Zheng, J., Wang, W., et al. Singapore grouper iridovirus disturbed glycerophospholipids homeostasis: Cytosolic phospholipase A₂ was essential for virus replication. Int. J. Mol. Sci. 22(22), 12597 (2021).