An immunosuppressant
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Napirimus

Item No. 41873

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-4-(1-naphthalenylcarbonyl)-1H-pyrrole-2-carboxylic acid
CAS Number
70696-66-1
Molecular Formula
C17H13NO3
Formula Weight
279.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C1=CC=CC2=C1C=CC=C2)C3=CN(C)C(C(O)=O)=C3
InChi Code
InChI=1S/C17H13NO3/c1-18-10-12(9-15(18)17(20)21)16(19)14-8-4-6-11-5-2-3-7-13(11)14/h2-10H,1H3,(H,20,21)
InChi Key
CNUPQURTHORUGH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $50

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    10 mg

    $95

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    25 mg

    $224

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    50 mg

    $396

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    Product Description

    Napirimus is an immunosuppressant.1 It is efficacious and preventative in a rat model of polyarthritis induced by complete Freund’s adjuvant when administered at doses of 200 and 100 mg/kg, respectively. Napirimus is 50 and 90% protective against experimental autoimmune encephalomyelitis (EAE), previously known as allergic encephalomyelitis, in rats when administered at doses of 100 and 400 mg/kg, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bessin, P., Mazarin, C., and Bonnet, J. Pharmaceutical compositions having immuno-suppressive properties. 4,617,315, (1986).