A mixture of cis-IRIB and trans-ISRIB
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ISRIB

Item No. 41879

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N′-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)-acetamide
CAS Number
548470-11-7
Molecular Formula
C22H24Cl2N2O4
Formula Weight
451.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(COC1=CC=C(C=C1)Cl)NC2CCC(CC2)NC(COC3=CC=C(C=C3)Cl)=O
InChi Code
InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)
InChi Key
HJGMCDHQPXTGAV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $54

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    10 mg

    $97

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    25 mg

    $162

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    50 mg

    $270

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    Product Description

    ISRIB is a mixture of the diastereomers and integrated stress response inhibitors cis-ISRIB and trans-ISRIB (Item No. 16258).1 trans-ISRIB inhibits gene transcription induced by activating transcription factor 4 (ATF4) more effectively than cis-ISRIB in a reporter assay using HEK293T cells (IC50s = 5 and 600 nM, respectively). trans-ISRIB decreases the latency to escape in the Morris water maze and increases the length of freezing time induced by contextual fear conditioning in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sidrauski, C., Acosta-Alvear, D., Khoutorsky, A., et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife 2:e00498, (2013).