A copper-free click chemistry reagent
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

DBCO acid

Item No. 41894

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11,12-didehydro-γ-oxo-dibenz[b,f]azocine-5(6H)-butanoic acid
CAS Number
1353016-70-2
Synonyms
  • Dibenzocyclooctyne Acid
Molecular Formula
C19H15NO3
Formula Weight
305.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(CCC(O)=O)N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2
InChi Code
InChI=1S/C19H15NO3/c21-18(11-12-19(22)23)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13H2,(H,22,23)
InChi Key
NDLOVDOICXITOK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $30

    Add

    100 mg

    $60

    Add

    500 mg

    $297

    Add

    1 g

    $594

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    DBCO acid is a copper-free click chemistry reagent.1,2 It has been used in the study of glycoprotein charge effects on the migration and invasion of 9-azido sialic acid-labeled cancer cells in vitro.1 DBCO has also been used in the synthesis of DBCO-modified RNase A to deliver RNase A into cancer cells labeled with tetraacetyl-N-azidoacetylmannosamine (AAM) in vitro and in vivo to induce cytotoxicity and reduce tumor growth, respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, M., Kejian, S., Ye, L., et al. Transforms of cell surface glycoproteins charge influences tumor cell metastasis via atypically inhibiting epithelial-mesenchymal transition including matrix metalloproteinases and cell junctions. Bioconjug. Chem. 34(8), 1498-1507 (2023).

    2. Zhao, Z., Zhang, Z., Duan, S., et al. Cytosolic protein delivery via metabolic glycoengineering and bioorthogonal click reactions. Biomater. Sci. 9(13), 4639-4647 (2021).