A linker molecule
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Product Categories

Product Type

Biochemicals
Synthetic Intermediates & Building Blocks

Research Area

Cancer

5-Maleimido-pentanoic NHS ester

Item No. 41900

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,5-dihydro-2,5-dioxo-1H-pyrrole-1-pentanoic acid, 2,5-dioxo-1-pyrrolidinyl ester
CAS Number
103750-03-4
Synonyms
  • 5-Maleimido-pentanoic N-hydroxysuccinimide ester
  • 5-Maleimido Valeric Acid-NHS
  • 5-Maleimido Valeric Acid-N-hydroxysuccinimide
Molecular Formula
C13H14N2O6
Formula Weight
294.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C(CCCCN1C(C=CC1=O)=O)ON2C(CCC2=O)=O
InChi Code
InChI=1S/C13H14N2O6/c16-9-4-5-10(17)14(9)8-2-1-3-13(20)21-15-11(18)6-7-12(15)19/h4-5H,1-3,6-8H2
InChi Key
ULZJAHZPCLFGHQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $54

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    100 mg

    $97

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    250 mg

    $190

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    500 mg

    $297

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    Product Description

    5-Maleimido-pentanoic NHS ester is a linker molecule.1 It has been used to conjugate SN-38 (Item No. 15632) to phlorizin (Item No. 11576) or phloretin (Item No. 14452) to increase the selectivity of SN-38 for cancer cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chiu, P.F., Chang, C.K., Huang, P.S., et al. Design, synthesis, and evaluation of glucose transporter inhibitor-SN38 conjugates for targeting colorectal cancer. J. Med. Chem. 66(14), 9681-9696 (2023).