An ionizable cationic lipid
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CP-LC-0867

Item No. 41926

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[4-[[2-(dimethylamino)ethyl]amino]-3-[(2-octyl-1-oxododecyl)amino]-4-oxobutyl]thio]-propanoic acid, 2-ethylhexyl ester
CAS Number
3040858-96-3
Molecular Formula
C39H77N3O4S
Formula Weight
684.1
Purity
≥98%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
O=C(C(NC(C(CCCCCCCCCC)CCCCCCCC)=O)CCSCCC(OCC(CC)CCCC)=O)NCCN(C)C
InChi Code
InChI=1S/C39H77N3O4S/c1-7-11-14-16-18-19-21-23-26-35(25-22-20-17-15-12-8-2)38(44)41-36(39(45)40-29-30-42(5)6)27-31-47-32-28-37(43)46-33-34(10-4)24-13-9-3/h34-36H,7-33H2,1-6H3,(H,40,45)(H,41,44)
InChi Key
MHSIWUYCHKAJPY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $164

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    10 mg

    $262

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    25 mg

    $575

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    Product Description

    CP-LC-0867 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of circular RNA (circRNA) and mRNA in vivo.1,2 Intramuscular administration of LNPs containing CP-LC-0867 and encapsulating circRNA encoding a luciferase reporter induce the production of luciferase protein for at least 14 days in mice.1 LNP-based vaccines containing CP-LC-0867 and encapsulating mRNA encoding the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein increase B- and T cell responses in mice with an increase in serum IgG titers and splenocyte IFN-γ levels, respectively, after six weeks.2 CP-LC-0867-containing LNP-based mRNA vaccines increase splenocyte IFN-γ levels in mice to a greater extent than vaccines containing CP-LC-0431 or CP-LC-0474.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Broset, E., Larraga, A., Lampaya, V., et al. A complete approach for circRNA therapeutics from purification to lyophilized delivery using novel ionizable lipids. Int. J. Mol. Sci. 26(11), 5138 (2025).

    2. Mata, E., Broset, E., Matute, C., et al. Preserved efficacy of lyophilized SARS-CoV-2 mRNA vaccine incorporating novel ionizable lipids after one year at 25 °C. NPJ Vaccines 10(1), 135 (2025).