A peptidomimetic antibiotic agent
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dAPM-1 (acetate salt)

Item No. 41943

Product Insert (PDF)
Technical Information
Formal Name
(S)-2-amino-N-(4-(((S)-2-Mamino-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamido)methyl)benzyl)-5-(3-((2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-yl)sulfonyl)guanidino)pentanamide, monoacetic acid
Synonyms
  • Diarginine Peptidomimetic-1
Molecular Formula
C46H68N10O8S2 • C2H4O2
Formula Weight
1013.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlH2O: Slightly Soluble: 0.1-1 mg/ml
SMILES
CC1=C2C(CC(C)(O2)C)=C(C(S(NC(NCCC[C@H](N)C(NCC3=CC=C(C=C3)CNC([C@@H](N)CCCNC(NS(=O)(C4=C(C)C(C)=C(OC(C)(C5)C)C5=C4C)=O)=N)=O)=O)=N)(=O)=O)=C1C)C.CC(O)=O
InChi Code
InChI=1S/C46H68N10O8S2.C2H4O2/c1-25-27(3)39(29(5)33-21-45(7,8)63-37(25)33)65(59,60)55-43(49)51-19-11-13-35(47)41(57)53-23-31-15-17-32(18-16-31)24-54-42(58)36(48)14-12-20-52-44(50)56-66(61,62)40-28(4)26(2)38-34(30(40)6)22-46(9,10)64-38;1-2(3)4/h15-18,35-36H,11-14,19-24,47-48H2,1-10H3,(H,53,57)(H,54,58)(H3,49,51,55)(H3,50,52,56);1H3,(H,3,4)/t35-,36-;/m0./s1
InChi Key
UWIJTCBXTYFLNU-AIHXPYQNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $83

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    Product Description

    dAPM-1 is a peptidomimetic antibiotic agent.1 dAPM-1 forms self-aggregates in the presence of dsDNA with a critical aggregation concentration (CAC) of 8 µg/ml. It selectively induces intracellular aggregation in B. subtilis over HEK293T cells at 128 µg/ml. It is active against S. aureus, methicillin-resistant S. aureus (MRSA), B. subtilis, E. faecium, and M. smegmatis (MICs = 8, 4, 4, 8, and 16 µg/ml, respectively) and is not cytotoxic to NIH3T3 or HK-2 cells (IC50s = >256 µg/ml for both). Extended exposure of S. aureus or E. coli to dAPM-1 for greater than 40 and 30 days, respectively, does not induce resistance to dAPM-1. In vivo, dAPM-1 (10 mg/kg) increases survival in a mouse model of sepsis induced by S. aureus.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kuhn, M. Molecular physiology of membrane guanylyl cyclase receptors. Physiol. Rev. 96(2), 751-804 (2016).