An ionizable cationic lipid
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Lipid U 105

Item No. 41944

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
di(heptadecan-9-yl) 6,6'-((3-(bis(2-hydroxyethyl)amino)propyl)azanediyl)dihexanoate
CAS Number
3049129-14-5
Molecular Formula
C53H106N2O6
Formula Weight
867.4
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Methyl Acetate: Soluble: ≥10 mg/ml
SMILES
CCCCCCCCC(CCCCCCCC)OC(CCCCCN(CCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)CCCN(CCO)CCO)=O
InChi Code
InChI=1S/C53H106N2O6/c1-5-9-13-17-21-27-36-50(37-28-22-18-14-10-6-2)60-52(58)40-31-25-33-42-54(44-35-45-55(46-48-56)47-49-57)43-34-26-32-41-53(59)61-51(38-29-23-19-15-11-7-3)39-30-24-20-16-12-8-4/h50-51,56-57H,5-49H2,1-4H3
InChi Key
RQVIWAFAIVHNAN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    Product Description

    Lipid U 105 is an ionizable cationic lipid (pKa = 6.65) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of circular RNA in vitro and in vivo.1 LNPs containing lipid U 105 and encapsulating circular RNA encoding VEGF-A increase the levels of VEGF-A in, and increases the proliferation and migration of, human umbilical vein endothelial cells (HUVECs). Topical administration of the same LNPs increases wound healing in a mouse model of diabetes induced by a high-fat and -sugar diet.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, J., Zhang, Y., Liu, C., et al. A single dose of VEGF-A circular RNA sustains in situ long-term expression of protein to accelerate diabetic wound healing. J. Control Release 373, 319-335 (2024).