A synthetic peptide
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals
Peptides

Research Area

Cancer
Neuroscience
Neuroendocrinology

DOTA-NOC (acetate)

Item No. 41975

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-3-(1-naphthalenyl)-L-alanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-L-cysteinamide, cyclic (2→7)-disulfide, acetate
Molecular Formula
C69H94N14O17S2 • XC2H4O2
Formula Weight
1455.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C(N[C@H](C(N[C@@](C(N1)=O)([H])[C@H](O)C)=O)CCCCN)[C@H](NC([C@@H](NC([C@H](CSSC[C@H]1C(N[C@@H]([C@H](O)C)CO)=O)NC([C@H](NC(CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=CC5=C4C=CC=C5)=O)CC6=CNC7=CC=CC=C67.CC(O)=O
InChi Code
InChI=1S/C69H94N14O17S2.C2H4O2/c1-42(85)55(39-84)76-68(99)57-41-102-101-40-56(77-64(95)52(31-44-13-4-3-5-14-44)72-58(87)35-80-23-25-81(36-59(88)89)27-29-83(38-61(92)93)30-28-82(26-24-80)37-60(90)91)67(98)75-53(32-46-17-12-16-45-15-6-7-18-48(45)46)66(97)74-54(33-47-34-71-50-20-9-8-19-49(47)50)65(96)73-51(21-10-11-22-70)63(94)79-62(43(2)86)69(100)78-57;1-2(3)4/h3-9,12-20,34,42-43,51-57,62,71,84-86H,10-11,21-33,35-41,70H2,1-2H3,(H,72,87)(H,73,96)(H,74,97)(H,75,98)(H,76,99)(H,77,95)(H,78,100)(H,79,94)(H,88,89)(H,90,91)(H,92,93);1H3,(H,3,4)/t42-,43-,51+,52-,53+,54-,55-,56+,57+,62+;/m1./s1
InChi Key
QHARHANTURNURK-JEFADWCOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $98

    Add

    5 mg

    $416

    Add

    10 mg

    $735

    Add

    25 mg

    $1,347

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    DOTA-NOC is a synthetic peptide composed of a derivative of the somatostatin receptor (SST) agonist octreotide (Item No. 23757) conjugated to the bifunctional chelator DOTA.1 It has been conjugated to radioligands for use in PET imaging of neuroendocrine tumors and for tissue distribution studies in vivo. 1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wild, D., Schmitt, J.S., Ginj, M., et al. DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labelling with various radiometals. Eur. J. Nucl. Med. Mol. Imaging 30(10), 1338-1347 (2003).

    2. Dam, J.H., Langkjær, N., Baun, C., et al. Preparation and evaluation of [18F]AlF-NOTA-NOC for PET imaging of neuroendocrine tumors: Comparison to [68Ga]Ga-DOTA/NOTA-NOC. Molecules 27(20), 6818 (2022).