An NTAQ1 degrader
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Product Categories

Product Type

Biochemicals

Research Area

Cell Biology
Proteolysis
Ubiquitin/Proteasome System

EM-12-FS

Item No. 41983

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[6-[(fluorosulfonyl)oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
CAS Number
2839138-44-0
Molecular Formula
C13H11FN2O6S
Formula Weight
342.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1NC(C(CC1)N2C(C3=CC(OS(=O)(F)=O)=CC=C3C2)=O)=O
InChi Code
InChI=1S/C13H11FN2O6S/c14-23(20,21)22-8-2-1-7-6-16(13(19)9(7)5-8)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6H2,(H,15,17,18)
InChi Key
RXYXBYLQECASPH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $98

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    10 mg

    $138

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    25 mg

    $318

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    Product Description

    EM-12-FS is a degrader of protein N-terminal glutamine amidohydrolase (NTAQ1), an enzyme involved in N-end protein degradation, and a derivative of (±)-thalidomide (Item No. 14610).1 It binds to cereblon (CRBN; IC50 = 256 nM) and covalently labels the histidine in position 353 (His353). EM-12-FS (1 and 5 µM) reduces the levels of NTAQ1 in MOLT-4 cells in a NEDDylation-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cruite, J.T., Dann, G.P., Che, J., et al. Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem. Biol. 3(9), 1105-1110 (2022).