An inducer of calcium influx
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Calcium Influx Inducer Compound 634

Item No. 41986

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2,1,3-benzothiadiazol-4-ylsulfonyl)amino]-4,5-dimethyl-3-thiophenecarboxylic acid, ethyl ester
CAS Number
882291-37-4
Molecular Formula
C15H15N3O4S3
Formula Weight
397.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/mlWater: Slightly soluble: 0.1-1 mg/ml
SMILES
O=S(NC1=C(C(OCC)=O)C(C)=C(C)S1)(C2=CC=CC3=NSN=C32)=O
InChi Code
InChI=1S/C15H15N3O4S3/c1-4-22-15(19)12-8(2)9(3)23-14(12)18-25(20,21)11-7-5-6-10-13(11)17-24-16-10/h5-7,18H,4H2,1-3H3
InChi Key
XVUDSTPMMKHHMW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Calcium influx inducer compound 634 is an inducer of calcium influx.1 It enhances the release of extracellular vesicles (EVs) from mouse bone marrow-derived dendritic cells (mBMDCs) when used at a concentration of 10 µM. Calcium influx inducer compound 634 (10 µM) also increases the levels of CD86 and CD80 on the surface of mBMDCs, an effect that can be blocked by the store-operated calcium entry (SOCE) inhibitor BTP2 (YM-58483; Item No. 13246), and increases CD86 and CD80 levels on mBMDC-derived EVs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sako, Y., Sato-Kaneko, F., Shukla, N.M., et al. Identification of a novel small molecule that enhances the release of extracellular vesicles with immunostimulatory potency via induction of calcium influx. ACS Chem. Biol. 18(4), 982-993 (2023).